A number of different reports have shown that adult stem cells can save limbs that might otherwise have been amputated. The most recent results, published in Bone Marrow Transplantation, reported salvage of legs in seven out of nine patients treated with their own peripheral blood adult stem cells. The paper also gives a nice summary of some of the previous clinical trials in this area.

Critical limb ischemia, the severe loss of oxygen to extremities, is an end-stage of peripheral artery disease (PAD). often results in amputation of the affected limb, and can be life-threatening. Cathy Ballzigler almost lost her life, but after receiving her own adult stem cells, both her life and her leg were saved. Tom Fisher is another example; he was facing amputation of his leg due to diabetic complications, but the leg was saved after injection of his own adult stem cells.

A few of the clinical trials currently available.

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