Comments on: Multiple Sclerosis Treatment with Adult Stem Cells

By: FRC Blog » Good News on Multiple Sclerosis with Adult Stem Cells

FRC Blog » Good News on Multiple Sclerosis with Adult Stem Cells — Tue, 11 May 2010 20:20:25 +0000

[...] Dr. Richard Burt at Northwestern University has published several studies showing good success using adult stem cells to “reboot” the immune system of MS patients. Scientists in Australia have also used the procedure with success, and recently Dr. Mark Freedman [...]

By: Douglas W. Cooper

Douglas W. Cooper — Fri, 01 Jan 2010 00:57:36 +0000

I bought and read a book on LDN as it applied to many illnesses, including MS. For MS, the improvements seemed to be consistent with the placebo effect. Perhaps there are different possible avenues of cure/improvement and LDN addresses some. Certainly, there were at least 50% non-improvement cases. We might have tried it but my wife’s chronic progressive quadriplegia is too painful to cease painkillers for the duration of the trial.

By: Bibekananda Hota

Bibekananda Hota — Thu, 31 Dec 2009 12:26:32 +0000

Does this works also for progressive MS ?

By: Jimmy Nunes

Jimmy Nunes — Fri, 25 Dec 2009 23:54:32 +0000

The first and complete book on heart failure and adult stem cells is in my library. It was written by author/researcher Christian Wilde and is called, Miracle Stem Cell Heart Repair. Actual patient stories and heart scans before and after. Also Edwin McClure’s wonderful success story beating MS is in the Wilde Stem Cell Research Report.

By: Cris Kerr

Cris Kerr — Sat, 19 Dec 2009 02:27:27 +0000

I agree. The sooner this is investigated, the sooner questions can be answered.

Penny, I don’t know how long you’ve been taking LDN, but I do know not all experience benefits. Of those who do, it can sometimes take 6 months or more.

I’m sorry you haven’t experienced any benefit yet. One of the many LDN patient support networks may help, beginning with the Yahoo lowdosenaltrexone group which has many long-term members with years of experience in MS & LDN.

By: Penny

Penny — Thu, 17 Dec 2009 00:52:21 +0000

I’m a chronic progressive, and have not, unfortunately, experienced any substantial benefit from LDN.

The causes, course of this disorder are many, and a one-size-fits-all treatment remains elusive.

By: FRC Blog » Multiple Sclerosis Treatment with Adult Stem Cells Treatment Me

FRC Blog » Multiple Sclerosis Treatment with Adult Stem Cells Treatment Me — Tue, 15 Dec 2009 08:07:34 +0000

[...] original here: FRC Blog » Multiple Sclerosis Treatment with Adult Stem Cells By admin | category: treatment | tags: are-attacking, involves-isolating, [...]

By: FRC Blog » Multiple Sclerosis Treatment with Adult Stem Cells « Blogging

FRC Blog » Multiple Sclerosis Treatment with Adult Stem Cells « Blogging — Tue, 15 Dec 2009 03:42:03 +0000

[...] Read more: FRC Blog » Multiple Sclerosis Treatment with Adult Stem Cells [...]

By: Cris Kerr

Cris Kerr — Mon, 14 Dec 2009 21:26:55 +0000

I don’t understand… everyone can write about MS treatments that have not been proven effective over extended periods of time for all forms of MS, yet will not write of treatments that patients themselves say have been effective for them over extended periods of time… and importantly, not just for Relapsing Remitting MS but also progressive forms of MS and other immune system diseases.

The free ebook ‘Those Who Suffer Much, Know Much’ available from LDN Research Trust in the UK contains 29 MS success stories presented as patient case studies. The book features a treatment patients themselves say is working for them, low doses of naltrexone (LDN)… or in other words, extremely low doses of an old drug with a good safety profile but unfortunately, unlike stem cells, one that happens to be long out-of-patent.

Understandably, with no profit potential the health industry has expressed zero interest in trialling this treatment, but even our health authorities are ignoring the potential of this lower cost, lower risk treatment.

This response may well be deleted as many have been before, but at least one more person will now be LDNAware.

(1) PILOT TRIAL NEWS – 1: Mult Scler. 2008 Sep;14(8):1076-83

A pilot trial of low-dose naltrexone in primary progressive multiple
sclerosis.

Gironi M, Martinelli-Boneschi F, Sacerdote P, Solaro C, Zaffaroni M,
Cavarretta R, Moiola L, Bucello S, Radaelli M, Pilato V, Rodegher M, Cursi
M, Franchi S, Martinelli V, Nemni R, Comi G, Martino G.

Institute of Experimental Neurology (INSPE) and Department of Neurology,
San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy;
Fondazione Don Carlo Gnocchi, IRCCS, Milan, Italy.

A sixth month phase II multicenter-pilot trial with a low dose of the
opiate antagonist Naltrexone (LDN) has been carried out in 40 patients with
primary progressive multiple sclerosis (PPMS).

The primary end points were safety and tolerability.

Secondary outcomes were efficacy on spasticity, pain, fatigue, depression,
and quality of life. Clinical and biochemical evaluations were serially
performed. Protein concentration of beta-endorphins (BE) and mRNA levels
and allelic variants of the mu-opiod receptor gene (OPRM1) were analyzed.

Five dropouts and two major adverse events occurred. The remaining adverse
events did not interfere with daily living. Neurological disability
progressed in only one patient.

A significant reduction of spasticity was measured at the end of the trial.
BE concentration increased during the trial, but no association was found
between OPRM1 variants and improvement of spasticity. Our data clearly
indicate that LDN is safe and well tolerated in patients with PPMS.

PMID: 18728058 PubMed – in process
http://www.ncbi.nlm.nih.gov/pubmed/18728058